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蒋丽丽

发布日期:2019-12-16    作者:     来源:    点击:

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个人概况

姓名:蒋丽丽   性别

职称:教授      导师资格:博导

单位:ag真人游戏网站app

学历:博士研究生        毕业院校:中山大学

招生专业:病理学与病理生理学

电子邮件:Jianglili@gzhmu.edu.cn

 

研究方向

肿瘤转移机制研究


所获荣誉

1. 广州市高层次人才(2019)

2. 霍英东教育基金会第十六届高等院校青年教师奖三等奖(2018)

3. 广州市三八红旗手(2018)

4. 广州市优秀女科技工作者(2018)

5. 广东省特支计划科技创新青年拔尖人才(2017)

6. 广东省青年珠江学者(2016)

7. 广东省杰出青年(2015)

8. 广州市珠江科技新星(2013)

9. 广东省高等学校“千百十工程”校级培养对象(2012)

10. 广州市羊城学者学术骨干(2012)


指导学生获得的科研项目和奖项

1. 2019年研究生国家奖学金 2人次

2. 2019年广州医科大学优秀研究生奖 1人

3. 2019年优秀三年级研究生学业奖学金 2人次

 

社会兼职

1. 广东省青联委员

2. 广东省青年科学家协会会员

3. 广州市青联委员


主持科研项目

(1) 国家自然科学基金面上项目,NCAPG促HER2+乳腺癌曲妥珠单抗的耐药作用及机制研究,55万,在研;

(2) 国家自然科学基金面上项目,癌基因Suprabasin促乳腺癌转移的生物学功能及其分子机制研究,60万,结题;

(3) 国家自然科学基金青年科学基金项目,蛋白酶体功能抑制负性调控蛋白合成的新途径,22万,结题;

(4) 广东省自然科学基金面上项目,TYRO3介导IL1α旁路激活NF-κB信号促乳腺癌肺转移的研究,10万,在研;

(5) 广东省自然科学基金面上项目,SBSN促膀胱癌侵袭转移的作用和机制研究,10万,在研;

(6) 广东省杰出青年科学基金,microRNA调控内质网应激途径抗肿瘤细胞凋亡的机制研究,100万,结题;

(7) 广东省自然科学基金面上项目,多个microRNA联合调控ERS信号通路影响肿瘤耐药性机制的研究及应用,10万,结题;

(8) 广东省省级科技计划项目,MicroRNA-30e-5p在JAK/STAT信号通路中的作用及其对胶质瘤诊治的临床意义,5万,结题;

(9) 广州市科技局基础与应用基础研究项目,SBSN促胶质瘤侵袭的作用和机制研究,20万,在研;

(10) 广州市教育系统创新学术团队项目,肿瘤侵袭转移机制研究创新团队,45万,结题;

 

部分代表性第一和通讯作者论文:

1. Lili Jiang#*, Liangliang Ren#, Han Chen#, Jinyuan Pan#, Zhuojun Zhang, Xiangqin Kuang, Xuhong Chen, Wenhao Bao, Chun Lin, Zhongqiu Zhou, Danping Huang, Jianan Yang, Hongbiao Huang, Lan Wang, Ning Hou, Libing Song*. NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2 positive breast cancer. Cell Death Dis. 2020 Jul.

2. Zhang X, Lin C, Song J, Chen H, Chen X, Ren L, Zhou Z, Pan J, Yang Z, Bao W, Ke X, Yang J, Liang Y, Huang H, Tang D, Jiang L*, Liu J*. Parkin facilitates proteasome inhibitor-induced apoptosis via suppression of NF-κB activity in hepatocellular carcinoma. Cell Death Dis. 2019 Sep 26;10(10):719.

3. Jiang L, Ren L, Zhang X, Chen H, Chen X, Lin C, Wang L, Hou N, Pan J, Zhou Z, Huang H, Huang D, Yang J, Liang Y, Li J*. Overexpression of PIMREG promotes breast cancer aggressiveness via constitutive activation of NF-κB signaling. EBioMedicine. 2019 May; 43:188-200.

4. Ren L, Chen H, Song J, Chen X, Lin C, Zhang X, Hou N, Pan J, Zhou Z, Wang L, Huang D, Yang J, Liang Y, Lili Jiang* MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis. Theranostics. 2019, 9(2):449-465.

5. Song J#, Xie C#, Jiang L#, Wu G, Zhu J, Zhang S, Tang M, Song L, Li J*. Transcription factor AP-4 promotes tumorigenic capability and activates the Wnt/β-catenin pathway in hepatocellular carcinoma. Theranostics. 2018 Jun 7; 8(13):3571-3583.

6. Jiang L, Zhou J, Zhong D, Zhou Y, Zhang W, Wu W, Zhao Z, Wang W, Xu W, He L, Ma Y, Hu Y, Zhang W, Li J*. Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells. Oncogenesis 2017, 13;6(3):e301. 

7. Jiang L, Yu L, Zhang X, Lei F, Wang L, Liu X, Wu S, Zhu J, Wu G, Cao L, Liu A, Song L, Li J*. miR-892b Silencing Activates NF-kappaB and Promotes Aggressiveness in Breast Cancer. Cancer Res 2016, 76 (5): 1101-1111. 

8. Jiang L, Zang D, Yi S, Li X, Yang C, Dong Xn, Zhao C, Lan X, Chen X, Liu S, Liu N, Huang H, Shi X, Wang X*, Liu J*. A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment. Sci Rep 2016, 6:21565.

9. Zhu J, Wu G, Li Q, Gong H, Song J, Cao L, Wu S, Song L, Jiang L*. Overexpression of Suprabasin is Associated with Proliferation and Tumorigenicity of Esophageal Squamous Cell Carcinoma. Sci Rep 2016, 6:21549.

10. Zhang X, Liu J, Zang D, Wu S, Liu A, Zhu J, Wu G, Li J, Jiang, L *. Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression. Oncotarget, 6 :15180-15193, 2015. 

11. Jiang, L.*, Wang C, Lei F, Zhang L, Zhang X, Liu A, Wu G, Zhu J, Song L*. miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway. Oncotarget, 6 :8286-8299, 2015. 

12. Jiang, L., Song, L., Wu, J., Yang, Y., Zhu, X., Hu, B., Cheng, S. Y., and Li, M*. Bmi-1 promotes glioma angiogenesis by activating NF-kappaB signaling. PLoS One, 8: e55527, 2013.

13. Jiang, L., Wu, J., Yang, Y., Liu, L., Song, L., Li, J., and Li, M*. Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway. BMC Cancer, 12: 406, 2012. 

14. Jiang, L., Lin, C., Song, L., Wu, J., Chen, B., Ying, Z., Fang, L., Yan, X., He, M., Li, J.*, and Li, M*. MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-kappaB/IkappaBalpha negative feedback loop. J Clin Invest, 122: 33-47, 2012. 

15. Jiang, L., Mao, P., Song, L., Wu, J., Huang, J., Lin, C., Yuan, J., Qu, L., Cheng, S. Y., and Li, J*. miR-182 as a prognostic marker for glioma progression and patient survival. Am J Pathol, 177: 29-38, 2010. 

16. Jiang, L., Li, J., and Song, L*. Bmi-1, stem cells and cancer. Acta Biochim Biophys Sin (Shanghai), 41: 527-534, 2009.